The influence of the ozonated physiological saline (OPS) on the oxidative metabolism and lipid peroxidation system in brain tissue of the intact animals and in the reduction period after the clinical death has  been studied. The OPS with the 135 mg/l ozone was infused to the intact rats at the background of the nembutal narcosis. The reperfusion period was studied at the 5 min clinical death model, the ozonised autoblood with the 80 mg/l ozone was inrtacarotid infused in the resuscitation period.

The influence of ozone both on the intact and hypoxic brain of rats in conditions of post resuscitation pathology was expressed in the neuron aerobic metabolism intensification and insignificant activation of peroxidation, causing the adaptive intensification of the cell antioxidant enzymatic system. In the period of reperfusion there is  the pentosophosphate way activation, directed to provision of the synthetic processes in the brain at the postresuscitation period.