Introduction

Malignant and nonmalignant tumors of uterine are the most common pathology in women of different age. The complex therapy of these patients includes radical surgery with hormonotherapy, polychemotherapy and radiation therapy. These methods have a whole number of side effects on a patient organism such as toxic and immunosuppressive effects as well as balance of pro- and antioxidant systems disorders [3; 5]. In this connection it is important to include in complex postoperative therapy auxiliary methods of treatment, which reduce intoxication, modify antioxidant protection level, normalize lipid peroxidation intensity and immunity. One of such methods is ozonetherapy. Treatment of a whole number of deseases including cancers demonstrates positive effects [1; 4; 5; 6; 7].

Immune system realizes elimination of tumor cells and restore the homeostasis of the organism. Reasonability of immunocorrecting therapy is identified if it changes immune cell repertoire and serum level of soluble immune cell membrane antigens or not [7; 10]. Also it is interesting to investigate lipid peroxidation process and antioxidant protection state. Some physicochemical forces can increase reactive oxygen species production and destroy tumor cells. So these forces can be used in anticancer therapy.

In this connection the aim of our research was to study the immunologic status before and after treatment with ozonized physiological saline in gynecologic patients with malignant and nonmalignant tumors for pathogenetic justification of ozone usage in persons suffering from hysteromyoma and endometrial cancer in the postsurgical period.