This study evaluates the outcome of ozone therapy given to 55 patients suffering from post-herpetic neuralgia, for whom “conventional” therapies brought no relief. The author makes several considerations regarding the assessment of pain, the details of ozone therapy, the coadjuvant medication, and the criteria for the evaluation of the results, i.e. the reduction or elimination of pain. From the statistical data the author concludes that ozone therapy is an effective therapeutic approach for post-herpetic neuralgia, especially when all other so-called “conventional” methods have failed.