An attempt to explain therapeutic efficacy of low doses of ozone due to its trigger properties has been made in the present article. The model of hypoxia in dogs has been used to reveal H+-ATP-ase activation This enzyme provides the conjugation of respiration and oxidative phosphorylation. There has been demonstrated activation of K+ -Na+ -ATP-ase which is responsible for concentration gradient of K+ and Na+ in intra- and intercellular space and, hence, for electric potential at rest. Analysis of proteolytic system in rats showed moderate activation of trypsin, chemotripsin and elastase in the intestine and in blood but not in the pancreas. Activation of kallikrein-kinin system triggers a number of metabolic processes and of blood coagulation system in particular. Correction of secondary messengers -cАМP and cGMP was found with the use of oncogenesis model in rats.