Ozone therapy has been reported to be effective in humans, but there was still small numbers of reports in veterinary medicine. Rectal insufflations (RI) of oxygen-ozone was effective as well as major ozone autohemotherapy (AHT), the procedure was easy to perform, painless, inexpensive and had no side effects. Subcutaneous (SC) injection of oxygen-ozone were also easy to perform for veterinarians. Ozone therapy were effective and may be used in conjunction with all conventional and natural