Introduction Last years it came to an increase in the number of patients with severe forms of rosacea, in particular this disease quite often develops in young people. A certain negative role in the development of complications is taken by irrational external therapy, in particular long-lasting uncontrolled applications of external corticosteroid preparations. It is known that a certain role in the pathogenesis of rosacea is taken by the disturbed metabolism of vasoactive peptides such as