105 pregnant women of a risk group with intrauterine fetus infection and newborns were examined. According to laboratory findings (levels of lipid peroxidation (LP) and antioxidant defense system (AODS), immune status, infectious agents in amniotic liquids, phagocytosis activation) the patients were divided into 2 groups, the 1st group comprising 60 intrauterine infection carriers without inflammation signs and the 2nd group of 45 patients showing the signs of the inflammatory process. Each group was subdivided into the trial group treated with ozone and control one with conventional methods of treatment. The patients received ozonated saline infusions intravenously for 3-5 days, ozone concentration- 800mcg/1.

The study demonstrated maximal therapeutic effect in patients of the 1st group (the normalization of LP and AOS indices ( 72%), improvement of immune indices (42%).78% of women with disturbances of uteroplacental blood flow showed a tendency to correction in dopplemetric indices. No cases of infectious agent transiting into a fetus were registered in the 1st group. The described effects were not revealed in the 2nd group Ozone was found to have its maximal effect in cases of TORCH infection agents being present without the signs of inflammatory process activation, thus, lessening the percentage of intrauterine fetus infection.